Randolph police on Wednesday raided a hotel room, seized nearly a pound of fentanyl, and arrested three men on drug trafficking charges.

Anyelo Medina-Jimenez, 34, of Providence, R.I.; Julio Carpio-Jimenez, 30, of Meriden, Conn.; and Juan Franjul Castillo of the Dominican Republic were all charged in trafficking in more than 200 grams of fentanyl. Castillo was also charged with trafficking in more than 10 grams of fentanyl.

The operation capped an investigation by Randolph Police detectives with assistance from the South Shore Drug Task Force and the Drug Enforcement Administration, according to a statement from Randolph Police Chief William Pace.

Detectives from the drug control unit were conducting surveillance around 2 p.m. Wednesday in the area of James Tighe Road when they witnessed a suspected drug transaction and conducted a traffic stop, police said

The driver later identified as Castillo, was arrested. Fentanyl found in his possession was seized, police said.

Detectives obtained a search warrant a short time later for a hotel room in the area of Route 138 in Randolph. During the search, police found and seized approximately 450 grams of fentanyl packaged for individual sale, $5,850 in cash, multiple cell phones and various narcotics-related packaging materials, police said.

Medina-Jimenez and Carpio-Jimenez were arrested at the hotel as a result of the search.

The estimated street value of the seized narcotics is approximately $45,000, police said. The three were due to be arraigned in Quincy District Court.

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