State police are investigating a wrong way crash on Interstate 495 in Wareham that ended up with three people in the hospital.

Police say just after midnight Friday they received reports of a vehicle driving south in the northbound lanes. As troopers were responding the wrong-way operator struck multiple vehicles.The wrong-way driver, as well as two people in vehicles that were struck, were injured.

One woman was trapped in the wreckage of her car. At least one victim has life-threatening injuries.The northbound lanes of the highway were shut down for about two hours. The crash remains under investigation.