Outfielder Jonny Gomes hit a grand-slam home run in the bottom of the first, and pitcher Jon Lester allowed just one hit through eight innings while striking out 15, and the Red Sox  held on for a 6-3 win over the Oakland A's Saturday at Fenway Park.

Gomes gave the Red Sox all the runs they needed in the first with a blast into the Monster Seats with the bases full.  David Ortiz and David Ross swatted solo shots in the third and fourth innings, respectively.

A's starter Tommy Milone allowed all six runs and took the loss.

Boston starter Jon Lester was masterful, shutting out Oakland for eight innings and allowing just one hit.  He struck out 15, a career high  Lester is now 3-4 on the season, with an ERA of 2.59.

The A's rallied in the ninth, scoring three runs off Chris Capuano before closer Koji Uehara entered the game and earned his 7th save.

The Sox and A's wrap up their series Sunday afternoon at Fenway.  A's righty Sonny Gray will oppose Boston's John Lackey.